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KMID : 0043320010240030190
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Archives of Pharmacal Research
2001 Volume.24 No. 3 p.190 ~ p.193
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Naphthaiarin Derivatives (Vll): Antitumor Action against ICR Mice Bearing Asfitic S-180 Cells
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Song GY
Kim Y/You YJ/Cho H/Ahn BZ
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Abstract
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Various analogues of 5,8-dimethoxy-1,4-naphthofuinone (DMNQ) such as 2-or 6-(1- hydroxyiminoalkyl)-DMNQs were prepared and evaluated for the antitumor action. (1- Hydr0xyiminoalkyl)-DMNQs derivatives expressed greater antitumor action than (1-hydroxyalkyl)- or acyl-DMNQ derivatives. Moreover 6-(1-hydroxyiminoalkyl)-DMNQ derivatives expressed higher autitumor action than 2-sudstituted ones, suggestive of a steric effect.Some of 6-(1-propyloxyalkyl)-DMNQ derivatives with an alkyl group of butyl to octyl moiety showed T/C values of>400%
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KEYWORD
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